Meredith Cochrane, GK-12 | Biology, UNCG

Meredith Cochrane, BioChemistry Master's Candidate


Meredith Cocrane

Meredith Cochrane works on the class of enzymes called the cytochrome P450s. These enzymes are present in nearly all life forms ranging from simple one-celled organisms to humans, and catalyze oxidative or reductive reactions in support of a variety of cellular functions. In humans, one of the primary functions is the removal of foreign chemicals (including many pharmaceutical agents) from the body. The enzymes use molecular oxygen and the cellular reducing agent NADPH to oxidize the foreign compounds which usually facilitates their elimination by a supporting class of enzymes called Phase II enzymes. Her project is focusing on the antioxidant effects of acai berry extract on CYP2E1 and CYP2A6 present in HepG2 cells and endothelial cells.